June 11th, 2018, Paderborn/Frankfurt – Achema 2018: With a complete, virtually realized multi-level production line, Lödige Process Technology will be demonstrating at Achema the characteristic strengths of continuous systems which may also find the interest of oral solid drug manufacturers.
Cost-effective manufacture of large product volumes was hitherto seen as the key argument in favour of continuous manufacturing processes. But there are a number of other advantages that weigh considerably in the pharmaceutical industry and make their use interesting for smaller throughputs. For example, these processes promise consistent product quality, enable smaller machines and involve less cleaning.
As a specialized vendor of machines for mixing, granulating and drying solids, Lödige has been implementing continuous solutions for many industries since the 1950s. Since that time the company has consistently enhanced its pharma-specific portfolio. Today, Lödige can realize the complete tablet production process – from the raw materials to the tablet-capable granulate.
Two basic manufacturing processes
Two basic manufacturing processes are available for the purpose:
1. In direct compressing the necessary components are fed into the process by container, big bag or small components via sack chutes. They are then transported by use of loss in weight feeders according to the specific composition, in the first step a continuous mixer creates a homogeneous mixture. The mixed product was either transported by gravity use or with pneumatic transport systems to the tablet press. Depending on the properties of the product, further machines may come into play between the mixer and tablet press, e.g. roller compactor.